Which medications in the drug class Leprostatics are used in the treatment of Erythema Dyschromicum Perstans?

Updated: Apr 19, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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These agents have both antimicrobial properties and anti-inflammatory properties. They were originally developed to treat tuberculosis.

Clofazimine (Lamprene)

Clofazimine is a lipophilic rhimophenazine dye with antimicrobial and anti-inflammatory properties originally developed to treat tuberculosis. It inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. Clofazimine has antimicrobial properties, but the mechanism of action unknown.

Although its mechanism of action is unclear, it seems to exert its main effect on neutrophils and monocytes in a variety of ways (eg, stimulating phagocytosis and release of lysosomal enzymes).

Dapsone (Avlosulfon)

Dapsone is bactericidal and bacteriostatic against mycobacteria; its mechanism of action is similar to that of sulfonamides, in which competitive antagonists of PABA prevent formation of folic acid, inhibiting bacterial growth.

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