What conditions are associates with erythema annulare centrifugum (EAC)?

Updated: Mar 06, 2020
  • Author: Dirk M Elston, MD; Chief Editor: William D James, MD  more...
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Other reported causes vary and include the following:

  • Foods: Blue cheese and tomatoes have been reported to cause EAC
  • Recurrent acute appendicitis: The lesions of EAC resolved 1 month after appendectomy. [8]
  • Cholestatic liver disease (secondary to choledocholithiasis): EAC resolved within 3 days of removal of the stone. [5]
  • Graves disease: The patient's eruption disappeared 2 weeks after treatment with I-131 for thyroid ablation. [6]
  • Menstruation: A case has been reported of a woman with EAC whose lesions stopped progressing premenstrually and enlarged again with the onset of menses. Another patient experienced exacerbations of EAC premenstrually as a type of autoimmune progesterone dermatitis. [29]
  • Hypereosinophilic syndrome: A patient with 31% eosinophilia (with no underlying cause found), pruritus, and EAC was treated with ketoconazole, dapsone, and trimethoprim-sulfamethoxazole with resolution of the eruption occurring after 2 weeks. [7]
  • Sjögren syndrome
  • Sarcoidosis: EAC was reported in association with underlying systemic sarcoidosis.
  • Osteoarthritis: A 73-year-old man with an 11-week history of EAC that was associated with the onset of left knee osteoarthritis received injections of intra-articular hyaluronic acid that effected resolution of both his osteoarthritis and the EAC. [30]
  • Stress: One report describes stress as an inciting factor in one case of EAC. The patient experienced EAC at the onset of stressful life periods, which abated without treatment upon discontinuation of the stressful period in the patient’s life. [31]
  • Pregnancy: One case report describes the onset of EAC during pregnancy, with resolution occurring shortly before delivery. [32] Other cases have remitted during pregnancy. [33]

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