Which malignancies cause erythema annulare centrifugum (EAC)?

Updated: Mar 06, 2020
  • Author: Dirk M Elston, MD; Chief Editor: William D James, MD  more...
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Answer

EAC resolved with successful treatment of the malignancy but relapsed with tumor recurrence in the cases of Hodgkin disease, acute myelogenous leukemia (AML), and squamous cell carcinoma in a sebaceous cyst. However, in the latter case, EAC cleared in the terminal stage of the disease. This was purported to be due to immune compromise with tumor progression. Note the following:

  • Squamous cell carcinoma (in a sebaceous cyst)
  • Nasopharyngeal carcinoma
  • Acute myelogenous leukemia
  • Peritoneal carcinomatosis
  • Primary bronchial carcinoid [25]
  • Hodgkin lymphoma [26, 27]
  • Chronic lymphocytic leukemia
  • Multiple myeloma
  • Prostate cancer
  • Malignant histiocytosis
  • Ovarian carcinoma (mucinous)
  • Breast cancer [28]

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