What is the role of antimalarials and beta-carotene in the treatment of polymorphous light eruption (PMLE)?

Updated: Jan 22, 2020
  • Author: Saud A Alobaida, MBBS, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antimalarials at low doses are sometimes helpful, especially in patients with a large papular variety of PMLE. A good-to-excellent response was reported by 68.9% of the patients who received hydroxychloroquine and by 63% of the patients who received chloroquine. [57]

Beta-carotene, which is effective in erythropoietic protoporphyria, may be an alternative to chloroquine. Oral carotenoid preparation (beta-carotene and canthaxanthin in a daily total dose of 100 mg) was compared to hydroxychloroquine (200 mg qd). [58] Both offered full sun tolerance in an equal but small percentage of patients when compared to a placebo.


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