How is epidermal nevus syndrome (ENS) treated?

Updated: Mar 26, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Answer

Therapy is often challenging. Epidermal nevi are usually resistant to topical and intralesional steroids, dithranol, topical retinoids, and cryosurgery. Topical calcipotriol may be effective. In the United States, calcipotriol is not approved for children younger than 12 years. [37, 38]

For Schimmelpenning syndrome, antiepileptic medications (if needed) should be promptly considered.

Inpatient care is indicated only when potentially serious or life-threatening medical problems result from internal defects of the brain, eyes, or skeleton.


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