What is the role of prophylactic therapy in the treatment of chronic granulomatous disease (CGD)?

Updated: Jul 29, 2019
  • Author: Roman J Nowicki, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Chronic granulomatous disease (CGD) in adults may be more common than previously assumed. Because timely treatment, infection prophylaxis, and genetic counseling for affected families are possible, CGD should be excluded in any patient with unexplained infections or granulomas. Patients with the disease should be counseled about prophylaxis for bacterial and fungal disease and avoidance of unnecessary exposure to mold and nonchlorinated water. Prophylactic therapy is based on daily doses of trimethoprim/sulfamethoxazole and itraconazole.

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