Which medications in the drug class Immune modulators are used in the treatment of Chediak-Higashi Syndrome?

Updated: Aug 08, 2019
  • Author: Roman J Nowicki, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Immune modulators

These agents inhibit key steps in immune reactions.

Immune globulin intravenous (Sandoglobulin, Gammagard, Gamimune, Gammar-P)

Intravenous immune globulin neutralizes circulating myelin antibodies through anti-idiotypic antibodies; down-regulates proinflammatory cytokines, including INF-gamma; blocks Fc receptors on macrophages; suppresses inducer T and B cells and augments suppressor T cells; blocks the complement cascade; promotes remyelination; and may increase CSF IgG (10%).

Interferon alfa-2a and -2b (Roferon-A, Intron A)

Interferon alfa-2a and -2b are protein products manufactured by recombinant DNA technology. Their mechanism of antitumor activity is not clearly understood; however, direct antiproliferative effects against malignant cells and modulation of host immune response may play important roles.

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