Which medications in the drug class Antineoplastic agents are used in the treatment of Chediak-Higashi Syndrome?

Updated: Aug 08, 2019
  • Author: Roman J Nowicki, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Antineoplastic agents

These agents inhibit cell growth and proliferation. Useful in the accelerated phase of the disease.

Vincristine (Vincasar PFS, Oncovin)

Vincristine's mechanism of action is uncertain. It may involve a decrease in reticuloendothelial cell function or an increase in platelet production. Reduce the dose by 50% if the direct bilirubin level is greater than 3 mg/100 mL.

Vinblastine (Alkaban-AQ, Velban)

Vinblastine inhibits microtubule formation, which, in turn, disrupts the formation of the mitotic spindle, causing cell proliferation to arrest at metaphase. Use hematologic parameters as a guide. If the direct bilirubin level is greater than 3, reduce the dose by 50%.

Local injection of hyaluronidase and application of moderate heat to the area of extravasation help disperse drug and are thought to minimize discomfort and the possibility of cellulitis.

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