Which medications in the drug class Antineoplastic agents are used in the treatment of Chediak-Higashi Syndrome?

Updated: Aug 08, 2019
  • Author: Roman J Nowicki, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Antineoplastic agents

These agents inhibit cell growth and proliferation. Useful in the accelerated phase of the disease.

Vincristine (Vincasar PFS, Oncovin)

Vincristine's mechanism of action is uncertain. It may involve a decrease in reticuloendothelial cell function or an increase in platelet production. Reduce the dose by 50% if the direct bilirubin level is greater than 3 mg/100 mL.

Vinblastine (Alkaban-AQ, Velban)

Vinblastine inhibits microtubule formation, which, in turn, disrupts the formation of the mitotic spindle, causing cell proliferation to arrest at metaphase. Use hematologic parameters as a guide. If the direct bilirubin level is greater than 3, reduce the dose by 50%.

Local injection of hyaluronidase and application of moderate heat to the area of extravasation help disperse drug and are thought to minimize discomfort and the possibility of cellulitis.


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