When was Chédiak-Higashi syndrome (CHS) first identified?

Updated: Aug 08, 2019
  • Author: Roman J Nowicki, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Answer

CHS was first described over 60 years ago by Beguez-Cesar (1943) in three siblings bearing the main clinical features of neutropenia and abnormal granules in leukocytes. Chédiak, a Cuban hematologist, reported another case in 1952, and, in 1954, Higashi, a Japanese pediatrician, described a series of cases characterized by misdistribution of myeloperoxidase in the neutrophilic granules of affected patients. [3, 4, 5]


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