What are the possible complications of ataxia-telangiectasia (A-T)?

Updated: Apr 06, 2020
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Early death is frequently due to pulmonary disease, but malignancies are also a common cause. The incidence of malignancy is 60-300 times higher than in healthy persons, and, on autopsy report, 49% of cases had malignant tumors. The most common tumors are lymphoreticular malignancies, especially non-Hodgkin lymphomas, but other kinds of tumors also occur. Malignancies are also more common in obligate heterozygotes than in the general population.


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