Which histologic findings are characteristic of granuloma gluteale infantum (GGI)?

Updated: May 27, 2021
  • Author: Marlene T Dytoc, MD, PhD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Answer

Granuloma gluteale infantum exhibits the following histologic characteristics [15] :

  • Parakeratotic stratum corneum

  • Hyperkeratosis and acanthosis of the epidermis

  • Dense, superficial, and deep inflammatory infiltrate composed of lymphocytes, histiocytes, plasma cells, and a variable number of focal aggregates of neutrophils and eosinophils forming microabscesses

  • Absence of foreign body giant cells

  • Dilatation, elongation, and proliferation of dermal blood vessels

  • Extravasation of red blood cells and deposits of hemosiderin

  • No fibrous proliferation, mitosis, or spindle cell formation

  • Presence of starch granules in the lesions

  • Intracytoplasmic structures resembling rickettsialike bodies within dermal macrophages

    Photomicrograph showing the histologic features of Photomicrograph showing the histologic features of a case of granuloma gluteale adultorum. Granuloma gluteale infantum shares identical histologic features (original magnification X100).
    Photomicrograph showing the histologic features of Photomicrograph showing the histologic features of a case of granuloma gluteale adultorum. Granuloma gluteale infantum shares identical histologic features (original magnification X450).

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