Which medications in the drug class Antihistamines are used in the treatment of Dermatologic Manifestations of Gianotti-Crosti Syndrome?

Updated: Aug 13, 2019
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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These agents prevent histamine response in sensory nerve endings and blood vessels. They are more effective in preventing histamine response than in reversing it.

Diphenhydramine (Benadryl, Benylin, Diphen, AllerMax)

Diphenhydramine is used for symptomatic relief of allergic symptoms caused by release of histamine. It competes with histamine for H1-receptor sites on effector cells.

Hydroxyzine hydrochloride (Atarax, Vistaril)

Hydroxyzine hydrochloride offers a mild degree of relief from pruritus. It antagonizes H1 receptors in the periphery. Hydroxyzine hydrochloride may suppress histamine activity in the subcortical region of the CNS.

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