Which lab studies are indicated in the workup of Gianotti-Crosti syndrome?

Updated: Aug 13, 2019
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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Laboratory studies are not generally indicated. Blood counts may reveal a lymphocytosis and a relative monocytosis or a lymphopenia secondary to an underlying viral infection, if present.

In cases associated with acute infection with the hepatitis B virus, EBV, or CMV, anicteric hepatitis is evident by elevations in the levels of hepatic transaminases and antiviral antibodies. A viral agent can be identified in approximately one third of cases. If a specific infectious etiology is suspected, testing can be directed at potential etiologies, as follows:

  • EBV - Monospot, immunoglobulin M (IgM) and immunoglobulin G (IgG) titers, or serum polymerase chain reaction (PCR)

  • CMV - IgM and IgG titers, serum CMV antigen levels, or serum PCR

  • RSV, parainfluenza virus, other respiratory viral pathogens - Nasal washing for fluorescent antibody testing or PCR

  • Enterovirus - Culture or PCR from serum

  • Parvovirus B19 - IgM and IgG titers or serum PCR

  • HHV-6 - Serum PCR

  • Group A beta-hemolytic streptococci - Serum PCR or pharyngeal culture

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