What are clinical findings of dermatologic manifestations of Gianotti-Crosti syndrome?

Updated: Aug 13, 2019
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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Answer

The cutaneous eruption of Gianotti-Crosti syndrome (papular acrodermatitis of childhood) is characterized by monomorphous pale, pink-to-flesh–colored or erythematous 1- to 10-mm papules or papulovesicles localized symmetrically and acrally over the extensor surfaces of the extremities, the buttocks, and the face. The number of lesions ranges from few to many. The trunk, knees, elbows, palms, and soles are rarely involved, and, in general, extensive involvement of the trunk is not consistent with a diagnosis of Gianotti-Crosti syndrome. Individual papules may coalesce to form larger plaques. Uncommonly, the eruption may develop a petechial or purpuric appearance. Partial involvement of only the face or the extremities is not uncommon, especially in older children. Over days to weeks, the papules may acquire a smooth-topped, polished, or lichenoid appearance. Other findings upon physical examination include the following:

  • Fever (27%)

  • Lymphadenopathy (31%)

  • Hepatosplenomegaly (4%)

  • Pharyngeal erythema, oropharyngeal ulcers or vesicles, or tonsillar swelling in cases secondary to infections of the upper respiratory tract

Note the images below.

Characteristic erythematous papules of Gianotti-Cr Characteristic erythematous papules of Gianotti-Crosti syndrome appear on the face of this child. The child does not have a toxic appearance.
Characteristic erythematous papules of Gianotti-Cr Characteristic erythematous papules of Gianotti-Crosti syndrome can be seen on the extremities, as is the case in this young child.
A 9-year-old girl who recently returned from a tri A 9-year-old girl who recently returned from a trip to Europe with her family. She developed a low-grade fever, malaise, and some lymphadenopathy. An eruption limited to her face, arms, legs, and buttocks was noted.
A mildly pruritic eruption characterized by erythe A mildly pruritic eruption characterized by erythematous papules localized to the face, arms, legs, and buttocks.

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