What is Gianotti-Crosti syndrome?

Updated: Aug 13, 2019
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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Gianotti-Crosti syndrome is a self-limited childhood exanthem that manifests in a characteristic acral distribution. It is rarely associated with systemic findings. The original cases, described in Italy by Gianotti in 1955, were associated with hepatitis B virus infection, although other viral infections currently account for most cases.

The two older, descriptive designations, papular acrodermatitis of childhood (PAC) and papulovesicular acrolocated syndrome (PAS), described indistinguishable clinical entities. PAC is the term most commonly used today.

Also see the Medscape Drugs & Diseases article Gianotti-Crosti Syndrome.

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