Which histologic findings are characteristic of branchial cleft cyst?

Updated: Jun 02, 2020
  • Author: Chih-Ho Hong, MD, FRCPC; Chief Editor: William D James, MD  more...
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Most branchial cleft cysts are lined with stratified squamous epithelium with keratinous debris within the cyst. In a small number, the cyst is lined with respiratory (ciliated columnar) epithelium. Lymphoid tissue is often present outside the epithelial lining. Germinal center formation may be seen in the lymphoid component, but true lymph node architecture is not seen. In infected or ruptured lesions, inflammatory cells are seen within the cyst cavity or the surrounding stroma.

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