How is aplasia cutis congenita (ACC) treated?

Updated: Jun 17, 2020
  • Author: Chris G Adigun, MD, FAAD; Chief Editor: William D James, MD  more...
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Answer

The decision to use medical, surgical, or both forms of therapy in aplasia cutis congenita (ACC) depends primarily on the size, depth, and location of the cutaneous defect and any therapy indicated for associated defects. The goal of treatment is to restore mechanical and immunological integrity of the skin and to limit fluid leakage or organ rupture. [32, 64, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75]

Local therapy includes gentle cleansing and application of a bland ointment or topical antibiotic ointment to prevent desiccation of the defect.

Antibiotics are only indicated if overt signs of infection are noted.

Other treatment is rarely necessary because the erosions and ulcerations almost always heal spontaneously.

A variety of specialized dressing materials have been used. [76, 77] Basic fibroblast growth factor has also been used as part of conservative treatment to accelerate healing and is suggested as a treatment to provide a better epithelium for future reconstruction in giant aplasia cutis congenita. [78]


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