Which histologic findings are characteristic of aplasia cutis congenita (ACC)?

Updated: Jul 31, 2018
  • Author: Joy Wan, MD, MSCE; Chief Editor: William D James, MD  more...
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Answer

The histologic features of the skin vary according to the depth of the aplasia and its duration. At birth, ulcerated lesions may show a complete absence of skin. After healing, the epidermis may appear flattened with a proliferation of fibroblasts within the connective-tissue stroma and an absence of adnexal structures. Bullous aplasia cutis congenita (ACC) is a rare clinical subtype with a distinct pattern containing fibrovascular stroma, edematous stroma, or both. Identical histologic findings are found in encephaloceles and meningoceles.


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