What is the pathophysiology of nail psoriasis?

Updated: Oct 03, 2019
  • Author: Cindy Li, DO; Chief Editor: William D James, MD  more...
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Answer

Answer

The pathogenesis of the psoriatic nail disorder is not completely known. Nail psoriasis may be due to a combination of genetic, environmental, and immune factors. A well-known fact is that a familial aggregation of psoriasis exists. Studies have linked psoriasis with certain human leukocyte antigen subtypes (eg, Cw6, B13, Bw57, Cw2, Cw11, B27). A T-cell–mediated inflammatory process is being investigated as part of the pathogenesis of psoriasis.


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