What is the role of empiric antimicrobial therapy in the treatment of guttate psoriasis?

Updated: Oct 16, 2020
  • Author: Kirstin Altman, MD; Chief Editor: Dirk M Elston, MD  more...
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However, the efficacy of antibiotics in the management of psoriasis has been questioned and data are limited. [50] Dogan et al and Owen et al found no statistically significant improvement in streptococcal guttate psoriasis after treatment with penicillin or erythromycin or with no treatment. [56, 57] Nevertheless, some experts have used empiric antimicrobial therapy in streptococcal-related guttate psoriasis, with the following agents [58] :

  • Cephalexin (Keflex)

  • Amoxicillin

  • Penicillin VK

  • Erythromycin

  • Rifampin

Azithromycin, which is commonly prescribed for community-acquired pneumonia, is likewise an option.

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