What is the role of genetics in the etiology of guttate psoriasis?

Updated: Oct 16, 2020
  • Author: Kirstin Altman, MD; Chief Editor: Dirk M Elston, MD  more...
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As in other types of psoriasis, genetic predisposition seems to play an important role in the development of an acute guttate psoriasis flare. [32]

Compared with control populations, a significant excess of HLA-BW17 has been found in patients with guttate psoriasis. Other researchers have found an increase in HLA-B13 positivity. Moreover, the inability to produce normal amounts of antibody to streptolysin-O by HLA-B13–positive individuals might explain their high prevalence of guttate psoriasis.

Interestingly, an increased prevalence of HLA-Cw6*0602 has also been found. These patients experience psoriasis at markedly higher rates than control subjects. [33, 34]

Thus far, psoriasis is the only disease associated with HLA-C gene expression. [16] HLA-B*57 and DRB1*07 have also been detected with increased frequency in psoriasis patients. [35]

Proteomic and immunohistochemistry studies have demonstrated that guttate psoriasis and chronic plaque psoriasis are phenotypically distinguishable in their protein expression patterns. [36, 37]

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