What is the role of genetics in the etiology of guttate psoriasis?

Updated: Oct 03, 2019
  • Author: Kirstin Altman, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Answer

As in other types of psoriasis, genetic predisposition seems to play an important role in the development of an acute guttate psoriasis flare. [27]

Compared with control populations, a significant excess of HLA-BW17 has been found in patients with guttate psoriasis. Other researchers have found an increase in HLA-B13 positivity. Moreover, the inability to produce normal amounts of antibody to streptolysin-O by HLA-B13–positive individuals might explain their high prevalence of guttate psoriasis.

Interestingly, an increased prevalence of HLA-Cw6*0602 has also been found. These patients experience psoriasis at markedly higher rates than control subjects. [28, 29]

Thus far, psoriasis is the only disease associated with HLA-C gene expression. [11] HLA-B*57 and DRB1*07 have also been detected with increased frequency in psoriasis patients. [30]

Proteomic and immunohistochemistry studies have demonstrated that guttate psoriasis and chronic plaque psoriasis are phenotypically distinguishable in their protein expression patterns. [31, 32]


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