What is the role of topical medications in the treatment of keratosis follicularis (Darier disease)?

Updated: Jul 31, 2018
  • Author: Pui-Yan Kwok, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Case reports have shown that topical retinoids (adapalene, [43, 44] tazarotene gel 0.01%, [45, 46] tretinoin [47] ) can reduce hyperkeratosis in 3 months. However, irritation is a limiting factor.

Emollients and topical corticosteroids can be used in combination with topical retinoids to reduce irritation.

Topical 5-fluorouracil (5-FU) has been used effectively in some patients. [48, 49]

Tacalcitol lotion and sunscreen combination therapy has been reported for localized Darier disease. [50]

Topical pimecrolimus has been reported to be successful in case reports. [51]

A Spanish group reported the use of the COX inhibitor diclofenac sodium 3% gel successfully in two patients. [52]

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