Which medications in the drug class Antibiotics are used in the treatment of Paronychia?

Updated: Oct 09, 2020
  • Author: Elizabeth M Billingsley, MD; Chief Editor: William D James, MD  more...
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Therapy must cover all likely pathogens in the context of this clinical setting.

Clindamycin (Cleocin)

This agent is a lincosamide used in the treatment of serious skin and soft tissue staphylococcal infections. It is also effective against aerobic and anaerobic streptococci (except enterococci). Clindamycin inhibits bacterial growth, possibly by blocking the dissociation of peptidyl transfer ribonucleic acid (t-RNA) from ribosomes, causing RNA-dependent protein synthesis to arrest.

Clindamycin widely distributes in the body without penetration of the central nervous system (CNS). It is protein bound and excreted by the liver and kidneys.

Amoxicillin and clavulanic acid (Augmentin, Augmentin XR, Amoclan)

This drug combination is used against bacteria resistant to beta-lactam antibiotics. In children over age 3 months, base dosing protocol on amoxicillin content. Because the amoxicillin/clavulanic acid ratio in 250-mg tablets (250/125) is different than in 250-mg chewable tablets (250/62.5), do not use 250-mg tablets until the child weighs more than 40 kg.

Penicillin VK

Penicillin VK inhibits the biosynthesis of cell wall mucopeptide. It is bactericidal against sensitive organisms when adequate concentrations are reached. It is most effective during the stage of active multiplication. Inadequate concentrations may produce only bacteriostatic effects.

Cephalexin (Keflex)

This is a first-generation cephalosporin that arrests bacterial growth by inhibiting bacterial cell wall synthesis. It has bactericidal activity against rapidly growing organisms, with primary activity against skin flora. It is used for skin infections or for prophylaxis in minor procedures.

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