Which medications in the drug class B Vitamins are used in the treatment of Necrobiosis Lipoidica?

Updated: Mar 06, 2020
  • Author: Cheryl J Barnes, MD; Chief Editor: George T Griffing, MD  more...
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B Vitamins

These agents may inhibit the synthesis of low-density lipoprotein and very-low-density lipoprotein. This inhibition results in a decrease of total plasma cholesterol. Nicotinamide, and not niacin or other niacin preparations, is a treatment option. [23] Nicotinamide is the physiologically active form of niacin, vitamin B-3. Unlike niacin, nicotinamide in high doses does not lower lipid levels or cause flushing. However, it does exert significant anti-inflammatory effects.

NADH (Nicotinamide adenine dinucleotide)

Nicotinamide moderates inflammatory reactions by inhibiting leukocytic chemotaxis and leukocytic release of lysosomal enzymes. It has been shown to inhibit lymphocytic transformation, antibody production, and mast cell degranulation.

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