What is the role of antiplatelet aggregation therapy in the treatment of necrobiosis lipoidica?

Updated: Mar 06, 2020
  • Author: Cheryl J Barnes, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Antiplatelet aggregation therapy with aspirin and dipyridamole has been tried owing to a belief that necrobiosis lipoidica results from platelet-mediated vascular occlusion or immune mechanisms that alter platelet survival. [7] These drugs are thought to prolong platelet survival time and, hence, prevent further worsening of necrobiosis lipoidica. The results of double-blind studies with aspirin and dipyridamole have varied but overall have shown some beneficial effects from the therapy.

Littler and Tschen reported a case of necrobiosis lipoidica that was treated successfully with pentoxifylline, a drug used in the treatment of intermittent claudication. [30] Pentoxifylline not only inhibits platelet aggregation but is also believed to decrease blood viscosity by increasing fibrinolysis and red blood cell deformity.


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