Which physical findings are characteristic of nodular localized cutaneous amyloidosis (NLCA)?

Updated: Nov 15, 2016
  • Author: Nicholas V Nguyen, MD; Chief Editor: Dirk M Elston, MD  more...
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Physical examination may reveal the following:

  • Firm nodules can present at any cutaneous site including the face, scalp, extremities, trunk and genitalia; however, acral areas are preferentially involved. [16, 17, 18, 19]

  • Nodules vary from a few millimeters to a few centimeters and may coalesce to form larger plaques.

  • Disseminated cases have been described. [20]

  • Nodules appear pink to brown or red.

  • Underlying epidermal atrophy has been described.

  • Other terms that describe the various lesions of nodular localized cutaneous amyloidosis include waxy, purpuric, yellowish, or bullous.

  • Lesions tend not to ulcerate.

  • Nodular localized cutaneous amyloidosis lacks extracutaneous findings by definition; however, one patient reported to have nodular localized cutaneous amyloidosis had amyloid deposits in the rectum.

  • Macroglossia, a typical feature of systemic amyloidosis, is not seen in nodular localized cutaneous amyloidosis.

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