How is acrodermatitis enteropathica treated?

Updated: Aug 21, 2019
  • Author: Kristina Marie Dela Rosa, MD; Chief Editor: William D James, MD  more...
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Treatment of acrodermatitis enteropathica requires lifelong zinc supplementation. Typically, 1-3 mg/kg of zinc gluconate or sulfate is administered orally each day. [9, 13] Clinical improvement occurs prior to any significant change in the plasma zinc levels, usually within days to weeks of initiating treatment. Monitor serum zinc levels and alkaline phosphatase values every 3-6 months. [9]

Acrodermatitis enteropathica exacerbation during pregnancy or the stress of disease may require an increase in therapy. [1, 31]

Warm compresses to remove the scale crust, followed by application of white petrolatum to eroded skin lesions, may enhance reepithelialization when used concurrently with zinc replacement.

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