Which physical findings are characteristic of acrodermatitis enteropathica?

Updated: Aug 21, 2019
  • Author: Kristina Marie Dela Rosa, MD; Chief Editor: William D James, MD  more...
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Answer

Physical signs and symptoms are as follows:

  • General: Infants are typically irritable and often inconsolable, and they show a slowing or cessation of growth and development.

  • Skin: Erythematous, dry, and scaly patches and plaques are present and may evolve into crusted, vesiculobullous, erosive, psoriasiform, and pustular lesions. Lesions are predominantly distributed in a periorificial and acral pattern and may become secondarily infected with Staphylococcus aureus or Candida albicans.

  • Mucosa: Findings include angular cheilitis, glossitis, conjunctivitis, blepharitis, punctate keratopathy, and photophobia.

  • Nails: Paronychia and nail dystrophy are typical.

  • Hair: Patients have loss of scalp hair, eyebrows, and eyelashes.

See the image below.

Sharply demarcated, brightly erythematous periorif Sharply demarcated, brightly erythematous periorificial plaque in an infant with acrodermatitis enteropathica.

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