What are the possible complications of acanthosis nigricans (AN)?

Updated: Oct 14, 2020
  • Author: Jason H Miller, MD; Chief Editor: William D James, MD  more...
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Complications vary depending on the etiology of acanthosis nigricans (AN). Appearance of acanthosis nigricans during childhood usually is associated with a benign condition, and no important sequelae are described.

Adult-onset acanthosis nigricans is more worrisome, and an underlying malignancy must be ruled out. However, most cases of adult-onset acanthosis nigricans are benign and often are associated with insulin resistance.

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