What is the prevalence of acanthosis nigricans (AN) in the US?

Updated: Oct 14, 2020
  • Author: Jason H Miller, MD; Chief Editor: William D James, MD  more...
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The exact incidence of acanthosis nigricans is unknown. In an unselected population of 1412 children, the changes of acanthosis nigricans were present in 7.1%. Obesity is closely associated with acanthosis nigricans, and more than half the adults who weigh greater than 200% of their ideal body weight have lesions consistent with acanthosis nigricans.

The malignant form of acanthosis nigricans is far less common, and, in one study, only 2 of 12,000 patients with cancer had signs of acanthosis nigricans. The most frequent associations were with adenocarcinomas of the gastrointestinal tract (70-90%), particularly gastric cancer (55-61% of malignant acanthosis nigricans cases).

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