What are the NCCN guidelines on adjuvant therapies for melanoma recurrence?

Updated: Oct 13, 2020
  • Author: Susan M Swetter, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

For local satellite/in-transit disease recurrence:

  • Primary treatment: Complete surgical excision to clear margins

  • Recommended options: Observation, nivolumab, pembrolizumab, combination dabrafenib/trametinib

For nodal recurrence:

  • Primary treatment: Excise nodal metastasis and complete lymph node dissection (if incomplete or no prior complete lymph node dissection)

  • Recommended options: Observation, high-dose ipilimumab (recommended only if patient has prior exposure to anti-PD1 therapy), nivolumab, pembrolizumab, combination dabrafenib/trametinib


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