Which medications in the drug class Bisphosphonate derivatives are used in the treatment of Langerhans Cell Histiocytosis?

Updated: Jun 12, 2020
  • Author: Christopher R Shea, MD; Chief Editor: William D James, MD  more...
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Bisphosphonate derivatives

These agents inhibit bone resorption by osteoclasts and in turn mitigate associated bone pain.

Zoledronate (Zometa)

Zoledronate is used to treat multiple myeloma and solid tumor bone metastases. It is also used for hypercalcemia of malignancy. It inhibits bone resorption, possibly by acting on osteoclasts or osteoclast precursors. The median duration of complete response (maintaining normalized calcium levels) and time to relapse is reported as 32 and 30 days, respectively. Administer daily calcium and vitamin D when used for multiple myeloma or metastatic bone disease.

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