Which age groups have the highest prevalence of Langerhans cell histiocytosis (LCH)?

Updated: Jun 12, 2020
  • Author: Christopher R Shea, MD; Chief Editor: William D James, MD  more...
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LCH affects patients from the neonatal period to adulthood, although it appears to be more common in children aged 0-15 years (reportedly approximately 4 cases per million population). [28] The age at onset varies according to the variant of LCH, as follows [3] :

  • Letterer-Siwe disease occurs predominantly in children younger than 2 years.

  • The chronic multifocal form, including Hand-Schüller-Christian syndrome, has a peak of onset in children aged 2-10 years.

  • Localized eosinophilic granuloma occurs mostly frequently in children aged 5-15 years.

  • Pulmonary LCH is more common during the third and fourth decades of life. [3]

Also see Histiocytosis.

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