What is the role of T-cell gene rearrangement testing in the workup of pityriasis lichenoides?

Updated: Sep 11, 2020
  • Author: Jeffrey P Callen, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

T-cell gene rearrangement studies to test for clonality may aid in the diagnosis of a lymphoma. It should be noted, however, that benign dermatoses also may show T-cell gene restriction and that the discovery of a clone is not a sine qua non of a lymphoma diagnosis. Several studies have shown a significant portion of pityriasis lichenoides cases have a T-cell clone. [5, 31]


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