What is the role of lab studies in the workup of pityriasis lichenoides?

Updated: Sep 11, 2020
  • Author: Jeffrey P Callen, MD; Chief Editor: Dirk M Elston, MD  more...
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Laboratory workup largely is a function of the acuity of the disease. A patient presenting with febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta (PLEVA) requires an entirely different approach than a patient presenting with pityriasis lichenoides chronica (PLC).

The following laboratory tests address both implicated causes of Mucha-Habermann disease and other disorders in the differential diagnosis; tailor the workup to each patient's presentation:

  • Antistreptolysin O titers

  • EBV IgM/IgG viral capsid antigen and nuclear antigen antibody

  • Erythrocyte sedimentation rate

  • Hepatitis B surface antigen, antisurface antibody, and anticore IgM

  • Hepatitis C virus antibody

  • HIV screening

  • Monospot or heterophil antibody test

  • Rapid plasma reagin

  • Throat cultures

  • Toxoplasma Sabin-Feldman dye test, enzyme-linked immunoassay, and indirect immunofluorescence/hemagglutination

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