Which medications in the drug class Immunomodulatory agents are used in the treatment of Pruritus and Systemic Disease?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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Immunomodulatory agents

Immunomodulatory agents are used to treat recalcitrant renal or cholestatic pruritus.

Thalidomide (Thalomid)

Thalidomide is thought to decrease T helper cells while inhibiting the production of TNF-alpha, which may induce itching. It has a strong central depressant effect that may decrease pruritus. Because of adverse events, attempt other treatments first.

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