Which medications may be used to treat renal pruritus?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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Other systemic therapies include nicergoline and free fatty acids (eg, those in primrose oil); these have shown positive results in reducing renal pruritus. Gabapentin has been shown to be effective in the treatment of chronic uremic pruritus, but it has been shown to worsen cholestatic pruritus. [41] Butorphanol, an opioid that displays mu antagonism and kappa agonism, has been shown to relieve uremic pruritus. [42] A newer kappa-opioid receptor agonist, nalfurafine, has been shown to be effective in significantly reducing pruritus in hemodialysis patients when compared to a placebo in a large, double-blinded, randomly controlled study. [13, 14]

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