What is the efficacy of oral opioid antagonists as a treatment for renal pruritus?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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Regarding opioid antagonists, studies of oral naltrexone have shown mixed results, with efficacy only in a small subset of patients. [36, 37]

Difelikefalin, a peripherally restricted selective kappa opioid receptor agonist, was shown to cause significant reduction in itch intensity and improved itch-related quality of life as compared with those receiving placebo in a group of hemodialysis patients. [38]

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