What systemic therapy is used in the treatment of renal pruritus?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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Answer

Systemic therapy includes UV-B and activated charcoal, which are first-line treatments, along with ensuring effective dialysis. [12, 29, 30, 31, 32, 33] Narrow-band UV-B is particularly effective. Oral activated charcoal is inexpensive, effective, and well tolerated; therefore, it is considered a reasonable treatment when UV therapy has failed. Activated charcoal is thought to prevent the absorption of an unknown pruritogen.

Cholestyramine is not as effective and is associated with adverse effects, such as acidosis.


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