Which histologic findings suggest a systemic cause of pruritus?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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Because skin lesions are most likely secondary to scratching, biopsy reveals nonspecific findings. Histologic features may include a hyperkeratotic epidermis with acanthosis and parakeratosis and elongation of the rete ridges. A perivascular lymphoid infiltrate may be present.

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