Which additional lab tests may be performed when initial findings are negative but a systemic cause of pruritus is still suspected?

Updated: Mar 03, 2020
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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When the results of initial laboratory screening are negative and when the physician still suspects a systemic cause, tests of the following may be ordered:

  • Serum protein electrophoresis

  • Stool for ova and parasites

  • Stool for occult blood (may reveal source for anemia)

  • Urine for hydroxy indole acetic acid (5-HIAA) and mast cell metabolites

Negative findings from the initial evaluation do not necessarily exclude systemic disease, and follow-up screening may be repeated every 3-6 months if clinical suspicion continues.

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