What is the role of lab testing in the workup of nephrogenic systemic fibrosis (NSF)?

Updated: May 22, 2018
  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Scleromyxedemalike skin lesions occur without associated paraproteinemia. Serum protein electrophoresis and immunoelectrophoresis results are negative.

Nephrogenic systemic fibrosis (NSF) occurs in the setting of renal disease. Thus, abnormal values of BUN and creatinine are typically present.

Thyroid studies produce normal findings in patients with nephrogenic systemic fibrosis.

In rare cases, peripheral eosinophilia has been noted.

In some cases, a positive antinuclear antibody test result has been reported.

Some patients with nephrogenic systemic fibrosis have anticardiolipin or antiphospholipid antibodies.

Rheumatoid factor and other autoantibodies are typically absent.

Many patients have an associated hypercoagulable state.

Some patients have hepatitis B or C.

In summary, no particular laboratory abnormality is consistently linked to nephrogenic systemic fibrosis.

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