Which age groups are at highest risk for nephrogenic systemic fibrosis (NSF)?

Updated: May 22, 2018
  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Nephrogenic systemic fibrosis has been reported in all age groups; persons of any age exposed to gadolinium may develop nephrogenic systemic fibrosis. The first group of persons reported with nephrogenic systemic fibrosis were adults whose ages ranged from 31-74 years. Data from the nephrogenic systemic fibrosis Registry indicate a range of ages from 8-87 years at the time of disease onset, with a mean age of 46.4 years. In 2003, Jan et al [39] reported on 2 pediatric cases. A series from England noted a patient in her 20s with the disease.

Children are generally not less able to develop nephrogenic systemic fibrosis. However, since new guidelines have been implemented, children who receive gadolinium have not developed nephrogenic systemic fibrosis. [40]

The development of nephrogenic systemic fibrosis is not correlated with the duration of renal failure, and it can occur early as well as later. Hancox et al [41] noted a case of nephrogenic systemic fibrosis after 5 days of hemodialysis.

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