What is the global prevalence of nephrogenic systemic fibrosis (NSF)?

Updated: May 22, 2018
  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Nephrogenic systemic fibrosis is an uncommon condition. Several case series from Europe have been reported. Four cases were described in a report in the British Journal of Dermatology in March 2003. [34] Additional cases have been reported in Germany and Switzerland.

For example, delayed-onset nephrogenic systemic fibrosis was reported in a Korean person with renal failure who demonstrated a "reverse superscan" on bone scintigraphy at age 19 years who had been exposed to gadolinium at age 14 years. [35]

A study in Denmark found a rate of 12 cases of nephrogenic systemic fibrosis per million, which may be the highest prevalence worldwide. [36]

In France, after new guidelines for use of gadolinium were instituted, a study of patients from 2009-2011 found that no cases of nephrogenic systemic fibrosis occurred. [37]


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