Which medications in the drug class Anticoagulant/antithrombolytic agents are used in the treatment of Cutaneous Cholesterol Emboli?

Updated: Apr 12, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Answer

Anticoagulant/antithrombolytic agents

Anticoagulant/antithrombolytic agents prevent, limit, or degrade thrombosis to reestablish blood flow.

Heparin (Hep-Lock)

Heparin augments the activity of antithrombin III and heparin cofactor to inhibit thrombin and factor Xa. It prevents conversion of fibrinogen to fibrin. It does not actively lyse but is able to inhibit further thrombogenesis. Heparin prevents reaccumulation of clot after spontaneous fibrinolysis, and it prolongs the aPTT.

Warfarin (Coumadin)

Warfarin interferes with hepatic synthesis of vitamin K–dependent coagulation factors (eg, II, VII, IX, X, proteins C and S). It is used for prophylaxis and treatment of venous thrombosis, pulmonary embolism, and thromboembolic disorders. Tailor the dose to maintain an INR of 2-3.


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