Which medications in the drug class Antiplatelet/antisludging agents are used in the treatment of Cutaneous Cholesterol Emboli?

Updated: Apr 12, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Antiplatelet/antisludging agents

Antiplatelet/antisludging agents prevent vascular occlusion.

Aspirin (Anacin, Bayer, Empirin)

Aspirin inhibits prostaglandin synthesis, preventing the formation of platelet-aggregating thromboxane A2. It may be used in a low dose to inhibit platelet aggregation and improve complications of venous stases and thrombosis.

Pentoxifylline (Trental)

Pentoxifylline may alter the rheology of RBCs, which, in turn, reduces blood viscosity.

Dipyridamole (Persantine)

Dipyridamole is used to complement usual warfarin therapy. It is a platelet adhesion inhibitor that possibly inhibits RBC uptake of adenosine, itself an inhibitor of platelet reactivity. In addition, it may inhibit phosphodiesterase activity, leading to increased cyclic-3',5'-adenosine monophosphate within platelets and formation of the potent platelet activator thromboxane A2.

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