What is the role of bisphosphonates in the treatment of calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Bisphosphonates (eg, pamidronate, [55, 56] etridronate [57] ) increase osteoprotegerin production and inhibit arterial calcification. Case reports suggest these may be helpful in some cases of calciphylaxis, even without changing calcium or phosphate levels. [53, 58, 59, 60] Parathyroidectomy should be considered if conservative management fails, but only if hyperparathyroidism is present.

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