What is the initial therapy for calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Therapy is multifaceted and includes medical and surgical intervention. [43, 44] Aggravating conditions should be addressed, and trigger factors should be eliminated. This may mean the discontinuation of parenteral iron therapy, calcium supplementation, and vitamin D supplementation. Cessation of warfarin therapy should be considered. Although frequently implicated as a trigger some studies suggest that patients may benefit from systemic glucocorticoids early on, unless ulcerated lesions are present. Early use of sodium thiosulfate should be considered. [45, 46]


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