Which patients are at an increased risk for calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Patients at an increased risk appear to be those who are obese and those who have been exposed to immunosuppressive agents, including glucocorticoids. [18] Calciphylaxis occurs more frequently in areas where body fat is most abundant, such as the thighs, the buttocks, and the lower part of the abdomen. [19, 20] Fatty areas may be at higher risk for thrombosis, owing to lower blood flow, increased potential for vascular kinking, or more likely, involvement of adipocytes in the pathogenesis of calciphylaxis. [24]

Persons with diabetes mellitus may also be at an increased risk; [18, 19, 20] insulin injections may be an independent risk due to trauma to the subcutis.

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