Which disorders are associated with the development of calciphylaxis?

Updated: Feb 24, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Disorders associated with the development of calciphylaxis include the following [3, 6, 18, 19, 20] :

  • Common associations include chronic renal failure, hypercalcemia, hyperphosphatemia, elevated calcium-phosphate product, hyperparathyroidism, and vascular calcification.

  • Noted associations include aluminum toxicity, coagulation abnormalities, and iron dextran infusion.

  • Associations suggested from clinical observations include renal transplantation, immunosuppressive agents, corticosteroid use, and obesity.

  • Systemic inflammation appears to be a predisposing factor. [12, 13]


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